Amberlyst-15 Catalyzed Cbz Protection of Amines Under Solvent-Free Conditions

Abstract

Amberlyst-15 can effectively catalyze Cbz protection of aliphatic and aromatic amines within 10–15 min under solvent-free conditions. The catalyst can be used repeatedly without loss of activity, and the reaction requires no workup and gives excellent yields.

Graphical Abstract

Keywords:

• Amberlyst-15
• amine
• Cbz
• solvent-free

ACKNOWLEDGMENTS

G.B. is grateful to the Council of Scientific and Industrial Research, New Delhi [Scheme No. 0 1 (1992)/05/EMR-II], and the Department of Science and Technology, New Delhi (Scheme No. SR/S1/OC-25/2007), for providing the financial assistance for this work.

Notes

^aAll the reactions were conducted at room temperature.

^bYield of the purified products.