Simple Strategy for Sulfonyl Ethynylogs of Coumarins

Abstract

Synthesis of 3-(2-(phenylsulfonyl) ethynyl)-2H-chromen-2-one is described. Reaction of β-ketosulfones with semicarbazide hydrochloride in ethanol at reflux temperature gave the corresponding semicarbazones, which on oxidative cyclization with selenium dioxide resulted in the formation of the corresponding 1,2,3-selenodiazole derivatives. These on pyrolysis gave the titled compounds.

Graphical Abstract

Keywords:

• Alkynes
• β-ketosulfones
• 1,2,3-selenodiazoles
• semicarbazones
• SeO2

ACKNOWLEDGMENT

Financial support from the Council of Scientific and Industrial Research, New Delhi, for the project (No. 01 (2062) 06/EMR-II) is gratefully acknowledged.