Facile Synthesis of β-Lactam-Grafted Spirooxindolopyrrolidine Through Regioselective 1,3-Dipolar Cycloaddition Reaction

Abstract

One-pot synthesis of novel β-lactam-grafted spiropyrrolidines has been accomplished in good yield via a facile [3 + 2] cycloaddition reaction of azomethine ylides, derived from β-lactam aldehyde and sarcosine, with various p-substituted (E)-2-oxoindoline-3-ylidene acetophenone derivatives as dipolarophiles. The reaction gave excellent yields of the products when carried out under microwave irradiation.

Graphical Abstract

Keywords:

• Azomethine ylide
• β-lactam
• cycloaddition
• microwave
• spiropyrrolidine

ACKNOWLEDGMENTS

The authors thank the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for financial support. One of the authors, N. A., thanks CSIR, New Delhi, for the award of junior and senior research fellowships.