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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 18
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Original Articles

Synthesis and Characterization of Novel Bi- and Tricyclic α-Amino Acids

, , , , , , , , & show all
Pages 2769-2793 | Received 06 May 2010, Published online: 29 Jun 2011
 

Abstract

As part of a medicinal chemistry collaboration, a number of novel bi- and tricyclic α-amino acids were prepared through various routes and characterized by 1H nuclear Overhauser effect difference experiments. The syntheses provide a number of routes to access some highly substituted amino acid derivatives that have not been reported previously. It is envisaged that the chemistry described here could be applied to the synthesis of other unique substrates.

Graphical Abstract

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