Samarium Triflate–Catalyzed Biginelli Condensation: An Improved Method for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

Abstract

A simple and efficient method for multicomponant synthesis of 3,4-dihydropyrimidinones has been reported. All the reactions were carried out using samarium triflate as catalyst (10 mol%) at acetonitrile reflux. This procedure is applicable to a variety of substrates such as aliphatic, aromatic, and heterocyclic aldehydes.

Graphical Abstract

Keywords:

• Aldehydes
• Biginelli reaction
• β-ketoester
• Sm(OTf)3
• urea

ACKNOWLEDGMENT

A. R. R. is thankful to the Council of Scientific and Industrial Research, New Delhi, for providing a fellowship.

Notes

^aAll the products were characterized by ¹HNMR, IR, and mass spectroscopy.

^bYields were isolated and unoptimized.