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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 18
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Original Articles

Tartaric Acid–Catalyzed Synthesis of α-Aminophosphonates Under Solvent-Free Conditions

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Pages 2800-2804 | Received 06 May 2010, Published online: 29 Jun 2011
 

Abstract

A facile procedure is developed for the synthesis of α-aminophosphonates, using tartaric acid as a stable, environmentally benign, low cost, and easily available organocatalyst. In the presence of tartaric acid (10 mol%), triethyl phosphite reacts with imines (generated in situ from an aldehyde and an amine) to yield the corresponding α-aminophosphonates. The organocatalyst tartaric acid is more stable during reaction. The catalyst provides easier workup, affords better yields, and takes less reaction time in comparison to generally used Lewis acid catalysts.

Graphical Abstract

ACKNOWLEDGMENT

The authors thank the Instrumentation Centre, Indian Institute of Technology, Roorkee, India, for obtaining NMR and IR spectra.

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