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Abstract
A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,N-dimethyl)amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.
ACKNOWLEDGMENTS
The present work has been supported by MEC Grant SAF2006-08764-C02-01, Comunidad de Madrid (S/SAL-0275-2006), Instituto de Salud Carlos III [RETIC RENEVAS (RD06/0026/1002)], and AECI (A/07492/07). A. S. thanks CSCI for the JAE-doc contract. M. C. thanks the Instituto de Salud Carlos III (Ministerio de Salud y Consumo) for a postdoctoral fellowship.
