Multicomponent Reaction for Synthesis of 2-(Indol-3-yl)pyridine Derivatives Under Microwave Irradiation

Abstract

A short, practical, and efficient preparation of 2-(indol-3-yl)pyridine derivatives via a one-pot procedure of 3-cyanoacetylindole, chalcones, and ammonium acetate under microwave irradiation was described. All these compounds were obtained in good yield, and their structures were confirmed by ¹H NMR, infrared, and elementary analysis.

Keywords:

• Chalcones
• 3-cyanoacetylindole
• 2-(indol-3-yl)pyridine derivatives
• microwave irradiation
• multicomponent reaction

ACKNOWLEDGMENT

This work was financially supported by the Research Foundation of Hebei University of Science and Technology.

Notes

^a The reaction was carried out under MW at 200 W.

^b Isolated yields.

^a Isolated yields.