Disodium Hydrogen Phosphate as an Efficient and Cheap Catalyst for the Synthesis of 2-Aminochromenes

Abstract

An efficient and convenient method for the synthesis of 2-aminochromene by the one-pot, three-component reaction of an aromatic aldehyde, malononitrile, and α- or β-naphthol in the presence of a catalytic amount of disodium hydrogen phosphate under solvent-free conditions is described.

Keywords:

• 2-Aminochromenes
• disodium hydrogen phosphate
• multicomponent coupling reactions
• solvent-free conditions

ACKNOWLEDGMENTS

We are grateful for financial support from the National Natural Science Foundation of China (20872025 and 21072042), the Natural Science Foundation of Hebei Province (B2011205031), and the Research Foundation for Undergraduate Scientific and Technological Innovation Project (0911105004).

Notes

^a Reaction condition: 4-chlorobenzaldehyde (1 mmol), malononitrile (1 mmol), and α-naphthol (1 mmol), catalyst (10 mmol%), 120 °C.

^b Yields refer to isolated pure products.

^a Reaction conditions: 4-chlorobenzaldehyde (1 mmol), malononitrile (1 mmol), and α-naphthol (1 mmol).

^b Yields are related to isolated pure products.

^a Isolated yield.