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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 23
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Original Articles

Efficient Synthesis of Bis(heterocyclyl)methanes

, &
Pages 3491-3496 | Received 25 Apr 2010, Published online: 04 Aug 2011
 

Abstract

The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.

ACKNOWLEDGMENT

This work was supported by financial assistance from the Department of Science and Technology (SR/S1/OC-27/2009).

Notes

a Isolated yield.

b Yields in parentheses refer to the use of 2.0 equiv of 3.

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