Abstract
Cassiferaldehyde, a recently discovered naturally occurring tyrosinase inhibitor, and six of its analogs, in which the aldehyde group has been replaced by various other functionalities, have been synthesized by a short and simple sequence starting from 2,3-dihydroxybenzaldehyde. Single-crystal x-ray structures of cassiferaldehyde as well as its methyl ketone, nitrile, and carboxylic acid analogs are reported.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
We thank the National Science Foundation for supporting this work through Grant No. CHE-0719335.