Green Synthesis of Quinazolinone Derivatives Catalyzed by Iodine in Ionic Liquid

Abstract

A series of quinazolinone derivatives were synthesized by the reaction of 2-aminobenzamides and triethyl orthoformate or triphosgene in ionic liquid of [BMIm]BF₄ at 80 °C catalyzed by iodine in good yields. Compared to other methods, this new procedure has the advantages of mild reaction conditions, good yields, operational simplicity, and environmentally friendly procedure.

GRAPHICAL ABSTRACT

Keywords:

• 2-Aminobenzamides
• ionic liquid
• quinazolinone
• synthesis

ACKNOWLEDGMENTS

We are grateful to the National Natural Science Foundation of China (20802061), the Natural Science Foundation (08KJD150019) of Jiangsu Education Committee, and the Qing Lan Project (08QLT001) for financial support.

Notes

^a Reaction condition: [BMIm]BF₄ (2 mL), 1 (2 mmol), 2 (0.311 g, 2.1 mmol), iodine (0.026 g, 0.1 mmol), 80 °C.

^a Reaction condition: [BMIm]BF₄ (2 mL), 1 (2 mmol), 4 (0.296 g, 1 mmol), iodine (0.026 g, 0.1 mmol), 80 °C.