Efficient Synthesis of Hydroxytyrosol from 3,4-Dihydroxybenzaldehyde

Abstract

Hydroxytyrosol is a naturally occurred orthodiphenolic component of olive oil. A variety of biological functions for this molecule have been reported. We report herein an efficient and practical method for the chemical synthesis of hydroxytyrosol from 2,3-dihydroxybenzaldehyde.

GRAPHICAL ABSTRACT

Keywords:

• Antioxidant
• hydroxytyrosol
• synthesis

ACKNOWLEDGMENTS

The financial support from Soochow University and the National Science and Technology Major Project on Key Drug Creation and Manufacturing Program (2009ZX09103-129) is gratefully acknowledged. We thank Professor Zhongwu Guo at Wayne State University and Professor Zhengqiang Wang at University of Minnisota for critical revisions.