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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 6
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Original Articles

N-Acyliminium Cyclization as an Approach for an Asymmetric Synthesis of the Pyrrolo[2,1-a]benzazepine Ring System

, , , &
Pages 872-882 | Received 01 Sep 2010, Published online: 11 Nov 2011
 

Abstract

In this article, we report a facile asymmetric synthesis of the pyrrolo[2,1-a]benzazepine ring system based around a stereoselective N-acyliminium cyclization of a novel chiral lactam template.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

The authors thank Loughborough University for facilities and the EPSRC Eng. D. program and Charnwood Molecular Ltd. for support to J. M. R. Towler. We also thank the STFC for synchrotron beam time at Daresbury Laboratory and J. E. Warren and T. J. Prior for scientific support on Station 9.8.

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