Convenient One-Step Synthesis of cis-2,4,5-Triarylimidazolines from Aromatic Aldehydes with Urea

Abstract

A simple and efficient method has been developed for the synthesis of cis-2,4,5-triarylimidazolines based on a one-step procedure of aldehydes and urea in the presence of cesium carbonate.

GRAPHICAL ABSTRACT

Keywords:

• Aldehyde
• cesium carbonate
• imidazoline
• urea

ACKNOWLEDGMENT

This work was supported by the National Natural Science Foundation of China (20972085 and 21032004).

Notes

^a The reactions were performed with 1.0 mmol aldehyde 1a, 4.0 mmol urea, and 2.0 mmol base in 2 mL solvent.

^b Determined by ¹H NMR using CH₂Cl₂ as internal standard.

^a NMR yields, isolated yields are given in parentheses.