Highly Efficient Method for the Synthesis of 1,4-Phenylenedithioureas Under Solvent- and Catalyst-Free Conditions Promoted by Microwave Irridiation

Abstract

A highly efficient method for the synthesis of 1,4-phenylenedithioureas promoted by microwave irridiation is reported. It is based on the nucleophilic addition reaction of 1,4-phenylenediisothiocyanate to aromatic amines under solvent- and catalyst-free conditions. The reaction has the advantages of short reaction time, good yields, and environmental acceptability.

GRAPHICAL ABSTRACT

Keywords:

• Microwave irradiation
• 1,4-phenylenediisothiocyanate
• 1,4-phenylenedithioureas
• solvent- and catalyst-free conditions

Notes

^a The power of MWI was 300 W.

^b Isolated yield based on 1,4-phenylenediisothiocyanate.

^a Materials were heated up to 60 °C in organic solvents.

^b Isolated yield based on 1,4-phenylenediisothiocyanate.

^a The power of MWI was 300 W at 60 °C.

^b Isolated yield based on 1,4-phenylenediisothiocyanate.