Microwave-Promoted Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)ones Using IL-ONO as Recyclable Base Catalyst Under Solvent-Free Conditions

Abstract

A mild, efficient, and solvent-free microwave (MW)–promoted Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)ones in nitrite ionic liquid (IL-ONO) is described. This ionic liquid is a weak Lewis base catalyst, which can be easily recovered and reused in several runs. The satisfactory results were obtained with good yields and short reaction time, using a simple experimental procedure.

GRAPHICAL ABSTRACT

Keywords:

• Biginelli
• dihydropyrimidinone
• microwave
• nitrite ionic liquid
• solvent-free

ACKNOWLEDGMENTS

The partial financial assistance from the research vice chancellor of Islamic Azad University of Mianeh and Azerbaijan University of Tarbiat Moallem is gratefully acknowledged.

Notes

^a Isolated yields of products.

^a Isolated yields of product.