Microwave-Assisted N-Cyclopropylation of Pyridinols with Cyclopropyl Boronic Acid

Abstract

Copper(II)-mediated N-cyclopropylation of pyridinols involving copper(II) acetate, pyridine, and NaHMDS under microwave conditions in a dry air atmosphere is described.

GRAPHICAL ABSTRACT

Keywords:

• Copper (II) acetate
• cyclopropyl boronic acid
• MW
• NaHMDS

ACKNOWLEDGMENT

We are thankful to Jubilant Chemsys Limited for funding our research work and providing the infrastructure support.

Notes

Notes. Reaction conditions: Substrate (1.0 equiv.), cyclopropyl boronic acid (2.0 equiv.), Cu(OAc)₂ (1.0 equiv.), pyridine (5.0 equiv.), NaHMDS (1.0 equiv.), dry air, and toluene.