Abstract
4-N-Arylamino-1-butanol derivatives are produced via a palladium-catalyzed tetrahydrofuran ring-opening reaction. This reaction occurs during the reduction of aromatic nitro groups with polymethylhydrosiloxane (PMHS) and potassium fluoride in the presence of hydrogen peroxide. This represents a novel route for the synthesis of 4-N-arylamino-1-butanols.
GRAPHICAL ABSTRACT
![](/cms/asset/d4315378-f54c-4790-9b7c-51070981c30d/lsyc_a_582978_o_uf0001.gif)
ACKNOWLEDGMENT
This research was supported by the National Institute for Cellular Biotechnology under the Programme for Research in Third Level Institutions (PRTLI, round 3, 2001-2006).
Notes
a No reaction.