Practical Preparation of Resveratrol 3-O-β-D-Glucuronide

Abstract

A practical synthesis of resveratrol 3-O-β-D-glucuronide, suitable for preparation of large quantities, was developed using selective deacetylation of resveratrol triacetate with ammonium acetate. A simplified procedure for large-scale preparation of resveratrol is also reported.

GRAPHICAL ABSTRACT

Keywords:

• Glucuronide
• preparation
• resveratrol

ACKNOWLEDGMENTS

This work was supported by the National Institutes of Health under Grant No. GM085645. We thank Alena Kubatova for HRMS analyses. The work on TOF MS was supported by the National Science Foundation under Grant No. CHE-0216038.