Alternative Synthesis of Valganciclovir Hydrochloride

Abstract

Synthesis of valganciclovir 1, a potent anticytomegalovirus (CMV) prodrug of ganciclovir 2, is described. The synthetic procedure involves protection–deprotection and reductive dehalogenation.

GRAPHICAL ABSTRACT

Keywords:

• Cytomegalovirus
• esterification
• protection
• reductive dehalogenation
• valganciclovir

ACKNOWLEDGMENTS

We greatly appreciate the supportive environment encouraged at Dr. Reddy's Laboratories Ltd. We are thankful to the Intellectual Property Management (IPM) and NMR Groups of Dr. Reddy's Research Foundation and the analytical group of Integrated Product Development Organization (IPDO) for their magnanimous support.

Notes

Communication No. IPDO-IPM-00239.