Abstract
Concise and alternative synthesis of zafirlukast (1) is described. The synthesis features fewer steps, convergent synthesis, and novel intermediates.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors are thankful to the management of Dr. Reddy's Laboratories Ltd., IPDO Bachupally, for supporting this work. Cooperation from colleagues at Dr. Reddy's Laboratories Ltd., IPDO, Bachupally, in analytical research and development is appreciated.
Notes
Dr. Reddy's Communication No. IPDO-IPM-0000238.