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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 5
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Original Articles

Stereoselective Addition of Grignard Reagents and Lithium Alkyls onto 3,5-Disubstituted-1,3-oxazolidine-2,4-diones

, , , &
Pages 749-757 | Received 29 Apr 2011, Published online: 13 Nov 2012
 

Abstract

3-Benzyl-5-methyl-1,3-oxazolidine-3,4-diones react with Grignard reactants and with lithium alkyls to yield 4-substituted 3-benzyl-4-hydroxy-5-methyl-1,3-oxazolidine-2-ones. The reaction is stereoselective and follows Cram's rule.

GRAPHICAL ABSTRACT

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