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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 10
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Original Articles

Synthesis of Ammonium 3,5-Dicyano-4-aryl-2,6-pyridinedionates with One-Pot Reaction of Aromatic Aldehydes, Amines, and Cyanoacetamide

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Pages 1413-1424 | Received 30 May 2010, Published online: 05 Mar 2013
 

Abstract

A simple and efficient synthesis of ammonium 3,5-dicyano-4-aryl-2,6-pyridinedionates was accomplished via one-pot, three-component reaction of aromatic aldehydes, amines, and cyanoacetamide. This unprecedented methodology had some potential advantages such as the common available starting material, short reaction time, good yield, broad substrate scope, and convenient operation.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

This work was financially supported by the National Natural Science Foundation of China (Grant No. 20972132) and the Key Laboratory of Environmental Resource and Material, Jiangsu Province.

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