Microwave-Assisted Amidation of Arylacetic Acids by Reaction with 2-Aryl-ethylamines

Alajos Grün Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary; Research Group of the Hungarian Academy of Sciences at the Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary

Mátyás Milen EGIS Pharmaceuticals, Division for Chemical Research, Budapest, Hungary

Tamás Földesi Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary

Péter Ábrányi-Balogh Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary

László Drahos Hungarian Academy of Sciences, Chemical Research Center, Budapest, Hungary

György Keglevich Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryCorrespondence[email protected]

Abstract

Twenty-five amides were synthesized in almost quantitative yields by microwave-assisted condensation of arylacetic acids and 2-aryl-ethylamines under solventless conditions. The N-arylethyl-arylacetylamides are intermediates of the corresponding isoquinoline derivates.

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ACKNOWLEDGMENTS

This project was supported by the Hungarian Scientific and Research Fund (OTKA K83118). This work is connected to the scientific program of the “Development of Quality-Oriented and Harmonized R+D+I Strategy and Functional Model at BME” project. This project is supported by the New Hungary Széchenyi Plan (Project ID: TÁMOP-4.2.1/B-09/1/KMR-2010-0002).

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Microwave-Assisted Amidation of Arylacetic Acids by Reaction with 2-Aryl-ethylamines

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Microwave-Assisted Amidation of Arylacetic Acids by Reaction with 2-Aryl-ethylamines

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GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

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