Mild and Efficient Synthesis of Benzo-Fused Seven- and Eight-membered Ring Lactams: A Convenient Approach to Biologically Interesting Chemotypes

Abstract

A general and efficient method for the synthesis of benzo-fused 7- and 8-membered ring lactams via the Beckmann rearrangement of cyclic oximes is presented.

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GRAPHICAL ABSTRACT

Keywords:

• Lactam
• medium ring
• methodology

ACKNOWLEDGMENTS

The authors thank Bayer Schering, the EPSRC, and Newman Trust for funding.

Notes

^a UPLC, ultraperformance liquid chromatography; rt, room temperature; h, hour.

^a See Supporting Information for synthesis of oxime substrates; equiv, equivalents; h, hour.