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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 11
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Original Articles

TBD-Catalyzed Trifluoromethylation of Carbonyl Compounds with (Trifluoromethyl)trimethylsilane

, &
Pages 1523-1529 | Received 10 Oct 2011, Accepted 22 Nov 2011, Published online: 06 Mar 2013
 

Abstract

Trifluoromethylation of carbonyl compounds using (trifluoromethyl) trimethylsilane catalyzed by 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding α-trifluoromethyl alcohols in good to excellent yields under mild reaction conditions.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

GRAPHICAL ABSTRACT

Notes

a 1 mol% of TBD was used.

b MTBD, 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene.

c TMG, tetramethyl guanidine.

a 10 mol% of TBD was used.

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