TBD-Catalyzed Trifluoromethylation of Carbonyl Compounds with (Trifluoromethyl)trimethylsilane

Abstract

Trifluoromethylation of carbonyl compounds using (trifluoromethyl) trimethylsilane catalyzed by 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding α-trifluoromethyl alcohols in good to excellent yields under mild reaction conditions.

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GRAPHICAL ABSTRACT

Keywords:

• Base catalyst
• guanidine
• organocatalyst
• organosilicon compounds
• trifluoromethylation

Notes

^a 1 mol% of TBD was used.

^b MTBD, 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene.

^c TMG, tetramethyl guanidine.

^a 10 mol% of TBD was used.