Abstract
The potassium metal can promote direct arylation of unactivated aromatic C-H bonds under an oxygen atmosphere. Interestingly, in situ demethoxylation, dechloridation, or decyanogenation from the corresponding coupling aromatic compounds mediated by potassium metal was also observed in the radical reaction systems.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
This work was supported by the National Natural Science Foundation of China (No. 21172210 and 20872135).
Notes
a Reaction was carried out under different atmosphere using iodo- or chloro-benzene (1: 1.5 mmol) and benzene (2: 20 mL, 225 mmol) in a three-necked flask.
b Isolated yield based on 1.
a The reaction was carried out under an oxygen atmosphere using aryl halide (1: 1.5 mmol) and benzene (2: 20 mL, 225 mmol) in a three-necked flask.
b Isolated yield based on 1.
c Possible by-product of KCN should be carefully treated!
d Biphenyl (3a) was also produced in about 8% yield.