Abstract
Aluminium chloride has been shown to be an efficient catalyst for the multicomponent reactions of diaminomaleonitrile (DAMN), ketones or aldehydes, and isocyanides for the synthesis of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives using comparative study with various catalysts. Unprecedented use of aromatic and aliphatic aldehydes in this multicomponent reaction (MCR) was demonstrated.
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GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
We are grateful to J. P. Chaudhary for NMR spectra and D. Gurav for IR spectra. S. M. B. is thankful to the Council of Scientific and Industrial Research, New Delhi, for financial support.
Notes
a Ref. [19].
b Intermediate imine isolated.