Mild and Efficient One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Nitriles Mediated by K₃PO₄

Abstract

Potassium phosphate, K₃PO₄, has been proved to be a cheap, strong, and efficient reagent for the one-pot synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from nitriles and acid chlorides under mild conditions.

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GRAPHICAL ABSTRACT

Keywords:

• Acid chlorides
• amidoximes
• nitriles
• 1,2,4-oxadiazoles
• potassium phosphate

ACKNOWLEDGMENTS

This work was supported by the Research Council of the K. N. Toosi University of Technology. The authors express their gratitude to Sogand Noroozizadeh for editing the English content of this manuscript.

Notes

^a Isolated yields.

^a References provided for known compounds.

^b Isolated yields.