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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 3
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Original Articles

Efficient Room-Temperature Synthesis and Antimicrobial Study of Novel 2-Aroylbenzofuran-3-ols from Substituted Methyl Salicylates and Phenacyl Bromides

, , , &
Pages 331-339 | Received 07 Mar 2013, Published online: 20 Nov 2013
 

Abstract

The article describes a convenient and efficient synthetic route for the construction of 2-aroylbenzofuran-3-ols from readily available diverse methyl salicylates and phenacyl bromides using K2CO3 as catalyst in dimethylformamide as solvent at room temperature. The reaction involves two steps, which occur in quick succession within 1 h to deliver the product with reasonably high yields. All the synthesized 2-aroylbenzofuran-3-ols (4a–u) were subjected for their antimicrobial studies, and some of these have shown prominent activity.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

GRAPHICAL ABSTRACT

ACKNOWLEDGMENT

The authors are thankful to the authorities of Jain University for financial support and encouragement.

Notes

Notes. ++++ = 15 mm, +++ = 11 mm, ++ = 8 mm, and + = 4 mm.

Notes. Each reaction took less than 1 h. Extra stirring time (15 min) was allowed to ensure that no traces of starting compounds were left.

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