Novel, Recyclable, and Thermally Stable Task-Specific Ionic Liquid (TBA Acetate) Medium/Catalyst for the Synthesis of Indolylidinecyclic-1,3- and -1,4-diketones

Abstract

A simple and efficient synthesis of indolylidinethiazolidnediones (3) and indolylidinecyclic-1,3-diketones (5) has been developed by reaction of indole-3-aldehyde (1) with thiazolidinedione (2) or cyclic-1,3-diketones (4) using tetra butyl ammonium acetate (TBAA) melt as novel, cost-effective, and recyclable ionic liquid under solvent-free green conditions at 100 °C for 15–20 min without additional use of catalyst.

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GRAPHICAL ABSTRACT

Keywords:

• Indolylidine cyclic-1,3-diketones
• indolylidinethiazolidinediones
• tetrabutylammonium acetate (TBAA)

ACKNOWLEDGMENT

The authors are thankful to the authorities of Jawaharlal Nehru Technological University, Hyderabad (A.P.), for providing laboratory facilities.

Notes

^a Reaction carried out on a 1-mmol scale.

^b Isolated yield.