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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 3
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Original Articles

Simple, Multicomponent, Ecofriendly, Microwave-Mediated Route for the Synthesis of Antimicrobial 2-Amino-6-aryl-4-(3H)-pyrimidinones

, , , &
Pages 374-380 | Received 15 Apr 2013, Published online: 20 Nov 2013
 

Abstract

In this work, we describe a multicomponent microwave-mediated synthesis of 10 2-amino-6-aryl-4-oxo-1,6-dihydro-pyrimidine-5-carbonitriles in good chemical yields (44–67%), four of them not related in earlier literature. All pyrimidinones synthesized herein had their antimicrobial activity evaluated against the following microorganisms: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Two of the synthesized substances displayed good antimicrobial activity against P. aeruginosa and S. aureus, two bacteria responsible for nosocomial infections.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

Our thanks are due to the Brazilian National Research Council (CNPq) and Pernambuco State's Scientific and Research Foundation (FACEPE, PRONEX-0788-1.06/08 CNPq, PRONEX/FACEPE/2008-0981-1.06/08, PPP/FACEPE/APQ-1225-1.06/10) for providing financial assistance. V. M. L. B. is grateful to INAMI (Nanotechnology for Nanomarkers Institute) for a technician's fellowship.

Notes

a MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration.

b Positive control.

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