Vilsmeier Reagent: An Efficient Reagent for the Transformation of 2-Aminobenzamides into Quinazolin-4(3H)-one Derivatives

Abstract

Clean and easy preparation of quinazolin-4(3H)-one derivatives using 2-aminobenzamides and Vilsmeier reagent is described. 2-Aminobenzamides were converted into the corresponding quinazolinones under mild and efficient conditions, in good yields without undesirable by-products.

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GRAPHICAL ABSTRACT

Keywords:

• 2-Aminobenzamides
• heterocycles
• isotoic anhydride
• 4(3H)-quinazolinones
• Vilsmeier reagent

ACKNOWLEDGMENTS

This research was supported by grants from the Research Council of Tehran University of Medical Sciences, the Iran National Science Foundation (INSF), and Iran National Elite Foundation (INEF).

Notes

^a Isolated yields.