Efficient Method for the Synthesis of α,α′-Bis(arylmethylidene) Cycloalkanones Catalyzed by Bromodimethylsulfonium Bromide

Abstract

Bromodimethylsulfonium bromide (BDMS)–catalyzed crossed aldol condensation between aromatic aldehydes and ketones is reported to access α,α′-bis(arylmethylidene) cycloalkanones at room temperature in good yields within 3–10 min. The salient features of this method are the simplicity of the procedure, the ready accessibility of the catalyst, and greater yields in relatively short reaction times.

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GRAPHICAL ABSTRACT

Keywords:

• α,α′-Bis(arylmethylidene) cycloalkanones
• bromodimethylsulfonium bromide (BDMS)
• crossed aldol condensation
• solvent-free

ACKNOWLEDGMENTS

This work was supported financially by Tianjin Normal University (Grant No. 5RL090), the Natural Science Foundation of Tianjin (Grant, Nos. 12JCZDJC34300, 11JCYBJC03600), and the Young Scientist Fund (Grant No.21001080).

Notes

^a Room temperature.

^b Isolated yield.

^a Room temperature.

^b Isolated yield.