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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 6
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Original Articles

One-Pot, Catalyst-Free Synthesis of Spirooxindole and 4H-Pyran Derivatives

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Pages 868-874 | Received 21 Jun 2013, Published online: 20 Feb 2014
 

Abstract

The synthesis of biologically valuable spirooxindoles and 4H-pyrans is described under catalyst-free conditions through sequential Knoevenagel–Michael–cyclization reactions from isatin or aromatic aldehyde, malononitrile, and 1,3-dicarbonyl compounds. The reaction conditions are very simple, providing excellent yield.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

The authors thank the Department of Science and Technology, New Delhi, for assistance under the IRHPA Program for the NMR facility at Madurai Kamaraj University and thank Orchid Chemicals and Pharmaceuticals Ltd. for providing facilities.

Notes

a Isolated yield.

a Isolated yield.

b The reaction was carried out at 70 °C.

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