Generating Encoded Compound Libraries for Fabricating Microarrays as a High-Throughput Protein Ligand Discovery Platform

Yung-Shin Sun Department of Physics, Fu-Jen Catholic University, New Taipei City, TaiwanCorrespondence[email protected]

Yiyan Fei Department of Optical Science and Engineering, Fudan University, Shanghai, China; Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Shanghai Ultra-Precision Optical Manufacturing Engineering Center, Fudan University, Shanghai, China

Juntao Luo Department of Pharmacology, Upstate Cancer Research Institute, State University of New York Upstate Medical University, Syracuse, New York, USA

Seth Dixon Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, University of California at Davis, Sacramento, California, USA

James P. Landry Department of Physics, University of California at Davis, Davis, California, USA

Kit S. Lam Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, University of California at Davis, Sacramento, California, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Sacramento, California, USA

Xiangdong Zhu Department of Physics, University of California at Davis, Davis, California, USA

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Abstract

We demonstrate an effective method for generating libraries of encoded compounds for fabricating large compound microarrays on solid supports. This method is based on one-bead, one-compound synthesis and employs a novel trilayer bead-partition scheme that ensures sufficient quantity of synthesized compounds releasable from each bead for compound microarray fabrication in high-throughput protein–ligand discovery assays.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]

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Generating Encoded Compound Libraries for Fabricating Microarrays as a High-Throughput Protein Ligand Discovery Platform

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Generating Encoded Compound Libraries for Fabricating Microarrays as a High-Throughput Protein Ligand Discovery Platform

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