Facile and Efficient One-Pot Procedure for Thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines Preparation

Abstract

Base-catalyzed cycloaddition reactions of heterocyclic azides with activated nitriles were studied. Convenient, efficient, and high-yield synthetic method for thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines preparation from available starting reagents without complicated protocols was elaborated. Such an approach allows creation of broad combinatorial libraries for drug discovery.

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GRAPHICAL ABSTRACT

Keywords:

• Domino reaction
• thieno[2,3-d]pyrimidin-4(3H)-one
• thiophene
• triazole