Abstract
A novel intramolecular asymmetric ketone-N-sulfinylimine pinacol-type reductive coupling reaction induced by SmI2 was reported. A series of 1-amino-1,2,3,4-tetrahydronaphthalen-2-carbinols were obtained in moderate to good yields with excellent ee and high dr.
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GRAPHICAL ABSTRACT
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Notes
a All reactions were reacted for 3 h.
b Isolated yield of the single diastereoisomer.
a dr was determined by 1H NMR of the crude products.
b Isolated yields of all diastereomers.