Abstract
Synthesis of entacapone from 4-iodo-2-methoxy-phenol with 2-cyano-N,N-diethylacrylamide by palladium-catalyzed Heck reaction, as a key step, is described.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors are grateful to Suven Life Sciences management for allowing them to publish these results and Dr. Vasanth Kumar for the preliminary laboratory work.