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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 9
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Original Articles

Synthesis of Entacapone by Pd-Catalyzed Heck Coupling Reaction

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Pages 1274-1278 | Received 27 Aug 2013, Published online: 28 Mar 2014
 

Abstract

Synthesis of entacapone from 4-iodo-2-methoxy-phenol with 2-cyano-N,N-diethylacrylamide by palladium-catalyzed Heck reaction, as a key step, is described.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

The authors are grateful to Suven Life Sciences management for allowing them to publish these results and Dr. Vasanth Kumar for the preliminary laboratory work.

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