Abstract
A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from α,β-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.
GRAPHICAL ABSTRACT
Notes
a All products were characterized by 1H NMR, 13C NMR, and IR data.
b Yields after purification by chromatography.
c Identified by comparison with authentic samples (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, and 37).
a All products were characterized by 1H NMR, 13C NMR, and IR data.
b Yields after purification by chromatography.
c Identified by comparison with authentic samples (31, 33, 34, and 36).