Novel Route for the Synthesis of 3-(Pyrrol-1-yl)-indolin-2-ones in Aqueous Micellar Medium

Abstract

A high-yielding environmentally benign protocol has been developed for the synthesis of 3-(pyrrol-1-yl)-indolin-2-ones from the reaction of isatin and trans-4-hydroxy-L-proline in aqueous micellar medium. The method is operationally simple and more effective than the previous methods in terms of the yield of the products and the reaction time.

GRAPHICAL ABSTRACT

Keywords:

• Isatin
• micelle
• 3-(pyrrol-1-yl)-indolin-2-ones
• reactions in water

Notes

^a Reactions performed using 1a and 2 in water at 80 °C for 30 min.

^b Yield of isolated pure product.

^c No reaction.

^a Reaction conditions: isatin (1 mmol), trans-4-hydroxy-L-proline (1 mmol), water (50 ml), CTAB (4 mmol), 30 min at 80 °C.

^b Yield of isolated pure products.