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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 44, 2014 - Issue 14
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Synthetic Communications Reviews

Advances in the Chemical Synthesis of Artemisinin

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Pages 1987-2003 | Received 12 Jan 2014, Published online: 09 Jun 2014
 

Abstract

Artemisinin, existing in the Chinese medicinal plant Artemisia annua L., is a kind of sesquiterpenoid lactone endoperoxide. It has received extensive attention from all over the world owing to its unusual trioxane structure and potent antimalarial properties. Here we demonstrate the complete chemical synthetic pathway of artemisinin, investigated the past three decades, including the total and partial syntheses.

GRAPHICAL ABSTRACT

Acknowledgments

Authors Zhonglei Wang and Liyan Yang contributed equally to this work.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.

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