Large-Scale Preparation of Long-Chain ADMET Synthons

Nicolas F. Sauty George and Josephine Butler Polymer Research Laboratory, Department of Chemistry and Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida, USA

Hong Li George and Josephine Butler Polymer Research Laboratory, Department of Chemistry and Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida, USA

Lucas Caire da Silva George and Josephine Butler Polymer Research Laboratory, Department of Chemistry and Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida, USA

Kenneth B. Wagener George and Josephine Butler Polymer Research Laboratory, Department of Chemistry and Center for Macromolecular Science and Engineering, University of Florida, Gainesville, Florida, USACorrespondence[email protected]

Abstract

We report a convenient process with minimal purification to produce large quantities of α,ω-alkenyl alcohols. These reagents are indispensable precursors in ADMET chemistry. Icos-19-en-1-ol, nonacos-28-en-1-ol, and octatriacont-37-en-1-ol were produced effortlessly in large quantities (up to 45 g in a single batch) from undec-10-en-1-ol. By extension of the method, any desired methylene run length in the ADMET precursor can be achieved.

GRAPHICAL ABSTRACT

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Large-Scale Preparation of Long-Chain ADMET Synthons

Information for

Open access

Opportunities

Help and information

Large-Scale Preparation of Long-Chain ADMET Synthons

Abstract

GRAPHICAL ABSTRACT

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature