Abstract
Facile, efficient, four-component domino reaction of dialkylphthalates, hydrazine hydrate, indole-3-carboxaldehydes, and malononitrile/ethyl cyanoacetate leads to the formation of 1-(1H-indol-2-yl)-1H-pyrazolo [1,2-b] phthalazine-5,10-diones in the presence of InCl3 as catalyst in refluxing ethanol for 1 h in good yields. This four-component domino reaction transformation presumably proceeds via sequential addition, dehydration, condensation, and cyclization steps.
GRAPHICAL ABSTRACT
![](/cms/asset/29fce1f4-189b-41dc-8f35-19be024b69be/lsyc_a_928326_o_uf0001.gif)
ACKNOWLEDGMENT
The authors are very thankful to the authorities of Jawaharlal Nehru Technological University Hyderabad for providing laboratory facilities.
Notes
a Refers to yields of crude products only.