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A concise 3-step synthesis of 3,5-dicyano-6-trifluoromethyl pyridine is reported from commercially available starting materials. Selective conversion of one cyano group into a thioamide offers further scope for derivatization.
We acknowledge the experimental skills of Audrey Le Gall, Nicolas Held, and Michael Frühauf, together with the analytical skills of Leonhard Hagmann.
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