Abstract
A biphenyl-based ligand attached was synthesized and screened in copper-mediated Michael reaction. The catalyst system works well with carbon or sulfur nucleophiles as Michael donors and cyclohexenone or chalcones as the acceptors under mild and neutral reaction conditions in a chemoselective manner.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
We thank N. D. Kulkarni and B. V. Kamath for their support and constant encouragement.
Notes
a For PhCOCH˭CHPh 7 (1.0 eq.), 1,2-dichloroethane.
b No reaction.
c With Cu(OAc)2.
d With CuCl2.
a With acetyl acetone (1.5 eq.), 1,2-dichoroethane, Cu(OTf)2 (10.0 mol %), 1 (5.5 mol %), rt, 6 d.
b Isolated.
c dr = 50:50.
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