Synthesis of 14,15-EET from Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant

Fuchun Xie Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA

Bingbing X. Li Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA

Nabil J. Alkayed Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA

Xiangshu Xiao Program in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USACorrespondence[email protected]

Abstract

14,15- Epoxyeicosatrienoic acid (14,15-EET) is an endogenous bioactive lipid with pharmacological benefits in multiple cardiovascular diseases. We describe here a practical synthesis of 14,15-EET from arachidonic acid using urea–hydrogen peroxide (UHP) as the oxidant.

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ACKNOWLEDGMENTS

We are grateful for Dr. Sanjiv Kaul for discussions and the Knight Cardiovascular Institute.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.

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Synthesis of 14,15-EET from Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant

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Synthesis of 14,15-EET from Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant

Abstract

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

Notes

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