Green Process Development for the Synthesis of Aliphatic Symmetrical N,N′-Disubstituted Thiourea Derivatives in Aqueous Medium

Abstract

A highly efficient green process for the synthesis of N,N′-disubstituted aliphatic thiourea derivatives using primary aliphatic amines and carbon disulfide in aqueous medium at room temperature via a nonisothiocyanate route is described. This protocol illustrates the rapid preparation of N,N′-disubstituted aliphatic thiourea derivatives in excellent yields with some advantages such as no catalyst and simple workup without any side product formation. Moreover the new route is concise, chromatography-free, and adaptable to pilot-scale preparation.

GRAPHICAL ABSTRACT

Keywords:

• Amine
• carbon disulfide
• catalyst free
• 1,3-disubstituted thioureas
• green synthesis
• water

View correction statement:

Corrigenda

ACKNOWLEDGMENT

The authors are thankful to University of Pune and SAIF, Punjab University, Chandigarh, for providing the spectral analysis.

Notes

^a Reaction conditions: (10 mmol) amine, (5 mmol) CS₂, and (0.5 mL) H₂O.

^b Isolated yields.

^c (2–3 mL) H₂O.

^a Reaction conditions: (0.6 mmol) amine, (0.3 mmol) CS₂, and (0.3 mL) solvent.

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.