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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 4
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Original Articles

Synthesis of Novel Dispiro 1,4-Benzothiazine Hybrid Heterocycles Through 1,3-Dipolar Cycloaddition

Karuppiah MalathiDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India
,
Veerappan JeyachandranDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India
,
Karumpan KalaiselvanDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India
&
Raju Ranjith KumarDepartment of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, IndiaCorrespondence[email protected]
Pages 503-512 | Received 27 Jun 2014, Published online: 31 Dec 2014
 
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Abstract

The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reaction of acenaphthylene-1,2-dione or isatins and α-amino acids to (E)-methyl/ethyl 2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-ylidene)acetate led to the stereoselective formation of novel dispiro 1,4-benzothiazine hybrid heterocycles in good yields.

GRAPHICAL ABSTRACT

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